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鈥淏ecause antidepressants, which are widely used around the world, are reported to increase the risk of bone fracture and reduce bone formation, we were curious to see how they might affect dental implants,鈥� says Prof. Faleh Tamimi, the lead author on the study and a professor in McGill鈥檚 School of Dentistry. 鈥淓ven so, we were surprised to discover that the negative effect of SSRIs on dental implants was so strong, almost equal to that of smoking, a well-established hazard for oral health.鈥�

The researchers reached this conclusion by looking back over the records of dental implants done over a six-year period, between 2007 鈥� 2013, in a clinic in Moncton, New Brunswick. Follow-ups took place with the patients between three and 67 months after the implant was done to see whether it had been successful.

Results of 916 dental implants done on 490 patients

听	Number of patients	Number of implants	Successful implants	Implant failures	Implant failures as a percentage of total number of implants done
Patients not taking SSRIs	439	822	784	38	4.62 %
Patients taking SSRIs	51	94	84	10	10.64%

鈥淯nfortunately, because this study was based on data collected after the implants had been done rather than through interviews with incoming patients, it is impossible right now to determine the kind of SSRI dosage that could have this effect,鈥� says Tamimi. 鈥淏ut what this study tells us is both that further work needs to be done in the field and that whether they are planning to have dental implants or hip or knee prostheses, SSRI users should consult their physicians and plan carefully to ensure that the surgical treatment is successful.鈥�

The research was funded by the China Scholarship Council, Clifford Wong Fellowship, Canadian Institutes of Health Research, Institute of Musculoskeletal Health and Arthritis Bridge Funding, and Le R茅seau de recherche en sant茅 buccodentaire et osseuse.

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To read the full text par X. Wu et al in the Journal of Dental Research

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To contact the researcher directly: faleh.tamimi [at] mcgill.ca

McGill Media Relations contact: katherine.gombay [at] mcgill.ca

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PHOTO: THINKSTOCK