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Cell Entrainment in a Mechano-Chemical Model of Collective Cell Migration

Andreas Buttenschoen, UMASS Amherst
Tuesday January 16, 12-1pm
Zoom Link:听
In Person: 550 Sherbrooke, Room 189
[Please note the speaker will be presenting in person]

Abstract:听Small GTPases, such as Rac and Rho, are well known central regulators of cell morphology and motility, whose dynamics also play a role in coordinating collective cell migration. Experiments have shown GTPase dynamics to be affected by both chemical and mechanical cues, but also to be spatially and temporally heterogeneous. While progress on understanding GTPase dynamics in single cells has been made, a major remaining challenge is to understand the role of GTPase heterogeneity in collective cell migration. Motivated by recent one-dimensional experiments (e.g. micro-channels) we introduce a one-dimensional modelling framework allowing us to integrate cell bio-mechanics, changes in cell size, and detailed intra-cellular signalling circuits (reaction-diffusion equations).

Using this framework, we build cell migration models of both loose (mesenchymal) and cohering (epithelial) tissues. We use numerical simulations, and analysis tools, such as bifurcation and local perturbation analysis, to provide insights into the regulatory mechanisms coordinating collective cell migration. We show how feedback from mechanical tension to GTPase activation lead to a variety of dynamics, including collective and individual cell migration phenotypes.