Event
QLS/CAMBAM Seminar - Dr. David Stephens
Thursday, February 8, 2018 12:00to13:00
McIntyre Medical Building
908, 3655 promenade Sir William Osler, Montreal, QC, H3G 1Y6, CA
Phylogenetic and Phylodynamic analysis of HIV infection in Montreal
David Stephens
McGill University
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In this talk I will discuss an analysis of HIV viral DNA samples collected in the Quebecprovincial genotyping program. The goal is to identify, from the genetic data, clustered samples that may correspond to contact (infection/transmission) networks, and to assess whether there is any evidence to support significant 鈥榩hylodynamic鈥� cluster development over time. The phylodynamic models utilized are based on standard SIR formulations which are integrated into a phylogenetic model. I will present an analysis of several hundred HIV DNA samples; the analysis is Bayesian, facilitated through Markov chain Monte Carlo.