Dr. George Zogopoulos
- Associate Professor
- Rosalind and Morris Goodman Cancer Institute
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MD, PhD, FRCSC, FACS
Currently supervising students
Pancreatic cancer
Hepato-Pancreato-Biliary and Abdominal Organ Transplant Surgery
Surgical treatment of pancreatic, biliary and hepatic malignancies as well as abdominal organ transplantation.
My research focuses on developing a translational research program in pancreatic cancer. My work focuses on elucidating the genetics of pancreatic cancer, investigating the therapeutic sensitivities of subsets of pancreatic cancer, translating these findings to clinical care, developing genetic and clinical screening strategies for individuals at a high life-time risk for pancreatic cancer, and establishing surgical treatment strategies for locally advanced pancreatic cancer. To pursue these research goals, I established a prospective clinic-based research registry for patients with pancreatic cancer and related conditions (the Quebec Pancreas Cancer Study), with an accompanying biospecimen repository and a patient-derived pancreatic cancer mouse xenograft program. My clinical interests include the surgical treatment of pancreatic, biliary and hepatic malignancies as well as abdominal organ transplantation.
Zanke B.W., Greenwood C.M., Rangrej J., Kustra R., Tenesa A., Farrington S.M., Prendergast J., Olschwang S., Chiang T., Crowdy E., Ferretti V., Laflamme P., Sundararajan S., Roumy S., Olivier J.F., Robidoux F., Sladek R., Montpetit A., Campbell P., Bezieau S., O'Shea A.M., Zogopoulos G., Cotterchio M., Newcomb P., McLaughlin J., Younghusband B., Green R., Green J., Porteous M.E., Campbell H., Blanche H., Sahbatou M., Tubacher E., Bonaiti-Pelli茅 C., Buecher B., Riboli E., Kury S., Chanock S.J., Potter J., Thomas G., Gallinger S., Hudson T.J., Dunlop M.G. A Colorectal Cancer Susceptibility Locus on Chromosome 8q24 Identified by a Genome-Wide Association Scan. Nature Genet. 39(8):989-94, 2007. PMID: 17415588
Zogopoulos G., Ha K.C., Naqib F., Moore S., Kim H., Montpetit A., Robidoux F., Laflamme P., Cotterchio M., Greenwood C., Scherer S.W., Zanke B., Hudson T.J., Bader G.D., Gallinger S. Germ-line DNA copy number variation frequencies in a large North American population. Hum Genet. 122(3-4):345-53, 2007. PMID: 1763801
Zogopoulos G., Rothenmund H., Eppel A., Ash C., Akbari M.R., Hedley D., Narod S.A., Gallinger S. The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer. Hum. Genet. 121(5):635-7, 2007. PMID: 17638019
Zogopoulos G., Jorgensen C., Bacani J., Montpetit, A, Lepage P., Ferretti V., Chad L., Selvarajah S., Zanke B., Hudson T., Pawson T., Gallinger S. Germline EPHB2 Receptor Variants in Familial Colorectal Cancer. Plos ONE 6;3(8):e2885, 2008. PMID: 18682749
Holter S., Pollett A., Zogopoulos G., Kim H., Schwenter F., Asai K., Gallinger S., Clendenning M., Steinbach G., Jacobson A., Boycott K.M. Hepatic Adenomas Caused by Somatic TCF1 Mutations in Children with Biallelic Mismatch Repair Gene Mutations. Gastroenterology 140(2):735-6, 2011. PMID: 21182953
