Dr. Jonathan Cools-Lartigue
Associate Professor
B.Sc with Great Distinction, MD, CM, PhDÂ
Currently supervising students
Cell Signaling, Host-Tumour Interaction and Lung Cancer Â
Elucidating the mechanisms by which systemic inflammation promotes tumor progression in patients with lung and esophageal malignacies. In particular, the understanding of the role of neutrophil extracellular traps in circulating tumor cell sequestration and tumor progression.Â
Dr. Cools-Lartigue’s clinical interests include general thoracic oncology with a focus on the management of esophageal malignancies. From a clinical standpoint, he hopes to push the envelope with regards to the implementation of minimally invasive techniques to esophageal surgery in an attempt to facilitate the enhanced recovery approach developed to a large extent at the Montreal General Hospital. He plans to do so through the application of advanced laparoscopic and robotic techniques to en bloc esophagectomy.Â
Interaction between tumor cells and the immune microenvironmentÂ
Dr. Cools-Lartigue is an Assistant Professor of Surgery at the McGill University Health Centre (MUHC) and attending surgeon at the Montreal General Hospital in the Division of Thoracic Surgery. He is also a Lead Researcher at the Research Institute of the McGill University Health Center (RI-MUHC) in Montreal Quebec Canada.Â
Dr. Cools-Lartigue his residency in General Surgery as well as his PhD in Experimental Surgery – now known as Surgical and Interventional Sciences – at McGill University in Montreal Quebec Canada. He was Chief Administrative Cardiothoracic Fellow at the Memorial Sloan Kettering Cancer Center in conjunction with the New York Presbyterian Hospital in Thoracic Surgery concentrating on esophageal cancer.Â
His PhD thesis manuscript entitled “Neutrophil Extracellular Traps Sequester Circulating Tumor Cells and Promote Metastasis” was truly groundbreaking and has become the central focus of his continued research in the Cancer field. This work represents a completely novel process and an exciting potential avenue for therapeutic intervention in the future. Most notably, the publications arising as a result of his doctoral thesis (Journal of Clinical Investigation – August 2013) have been widely reported in the global lay media including National Public Radio, Australian Broadcasting Corporation, and Radio Canada. In addition, this research was cited as one of the top 10 discoveries of 2014 by Quebec Science magazine and was recognized as one of the top ten cancer discoveries of 2013 by the Canadian Cancer Society. Â
